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Small Volume Dissolution and Membrane Permeation Measurement System 'μDISS・μFLUX'

Small Volume Dissolution and Membrane Permeation Measurement System 'μDISS・μFLUX'

It is possible to evaluate elution and membrane permeability simultaneously with a small volume!

*μDISS This is a system that combines the Rainbow and Mini-Bath manufactured by Pion. It uses a 25mL glass vial, allowing for solubility measurements in small volumes. In addition to solubility measurements, it can also be used for salt screening and supersaturation evaluation. *μFLUX This is a system that combines a dedicated H-shaped chamber. By using two probes from the Rainbow, it is possible to evaluate dissolution on the donor side and membrane permeability (absorption) on the acceptor side, separated by an artificial membrane. It allows for the evaluation of the effects of formulations on dissolution and membrane permeability, as well as the impact of meals.

  • uFLUX.png
  • Dissolution Tester

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[Case Study of Membrane Permeability Measurement System] Evaluation of Membrane Permeability Using μFLUX

[Case Study of Membrane Permeability Measurement System] Evaluation of Membrane Permeability Using μFLUX

Explaining the effect of pH modifiers on the membrane permeability of diclofenac!

We would like to introduce a case study on the application of the membrane permeability measurement system "μFLUX." In our previous research, we developed a sustained-release formulation containing an alkalizer, and we attempted to apply this device to evaluate its usefulness in reducing gastric mucosal damage caused by DC. In this study, we only simulated the pH environment, but incorporating other components such as lipids and proteins is expected to lead to a more accurate evaluation. 【Case Overview】 ■ Study - Evaluated the impact of pH fluctuations in the microenvironment caused by the alkalizer on the membrane permeability of the acidic drug DC using μFLUX. ■ Results - It was demonstrated that μFLUX could be a useful tool not only for evaluating drug absorption but also for assessing the risk of side effects caused by drug accumulation in tissues. *For more details, please download the PDF or feel free to contact us.

  • 膜透過性評価2.png
  • Other measurement and measuring equipment

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Small volume dissolution and membrane permeation measurement system 'μDISS・μFLUX'

Small volume dissolution and membrane permeation measurement system 'μDISS・μFLUX'

Immediate data acquisition with fewer APIs. Significantly reduces time and costs from measurement to analysis, contributing to cost reduction in formulation research and improved evaluation speed.

The μDISS and μFLUX are small-volume measurement systems that can evaluate solubility and membrane permeability with a small amount of API. They allow testing to proceed even in the early stages of development when the API is limited. ■ μDISS It enables dissolution testing on a small scale. Since dissolution data can be obtained immediately after measurement, sampling and waiting times are minimized. By shortening the process up to data analysis, it contributes to speeding up the overall research. ■ μFLUX It can simultaneously evaluate solubility and membrane permeability, allowing for a more realistic prediction of in vivo absorption. It enables the understanding of differences in absorption even with small amounts of API, and by reducing the workload, it achieves efficiency in both time and cost. It also allows for the examination of multiple conditions and comparative tests without difficulty. Both systems are suitable evaluation solutions for research environments that want to obtain materials for formulation design and formulation consideration more quickly and reliably. For more details, please check the "Download Catalog" below or feel free to contact us.

  • uFLUX.png
  • Dissolution Tester

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